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Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

Therapeutic targeting of estrogen receptor-α (ERα) by the anti-estrogen tamoxifen is standard of care for premenopausal breast cancer patients and remains a key component of treatment strategies for postmenopausal patients. While tamoxifen significantly increases overall survival, tamoxifen resistan...

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Detalles Bibliográficos
Autores principales:	Pulliam, Nicholas, Tang, Jessica, Wang, Weini, Fang, Fang, Sood, Riddhi, O’Hagan, Heather M., Miller, Kathy D., Clarke, Robert, Nephew, Kenneth P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357000/ https://www.ncbi.nlm.nih.gov/pubmed/30621214 http://dx.doi.org/10.3390/cancers11010043

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