Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis

Human inflammatory or neurodegenerative diseases, such as progressive multiple sclerosis (MS), occur on a background of age-related microglia activation and iron accumulation as well as pre-existing neurodegeneration. Most experimental models for CNS diseases, however, are induced in rodents, which...

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Detalles Bibliográficos
Autores principales: Wimmer, Isabella, Scharler, Cornelia, Zrzavy, Tobias, Kadowaki, Taro, Mödlagl, Verena, Rojc, Kim, Tröscher, Anna R., Kitic, Maja, Ueda, Shuichi, Bradl, Monika, Lassmann, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357376/
https://www.ncbi.nlm.nih.gov/pubmed/30704526
http://dx.doi.org/10.1186/s40478-019-0667-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357376/
https://www.ncbi.nlm.nih.gov/pubmed/30704526
http://dx.doi.org/10.1186/s40478-019-0667-9

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