Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

BACKGROUND: Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbations indicates a need to improve ICS actions. METHODS: Glucoc...

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Detalles Bibliográficos
Autores principales: Mostafa, Mahmoud M., Rider, Christopher F., Shah, Suharsh, Traves, Suzanne L., Gordon, Paul M. K., Miller-Larsson, Anna, Leigh, Richard, Newton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357449/
https://www.ncbi.nlm.nih.gov/pubmed/30704470
http://dx.doi.org/10.1186/s12920-018-0467-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357449/
https://www.ncbi.nlm.nih.gov/pubmed/30704470
http://dx.doi.org/10.1186/s12920-018-0467-2

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