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Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

BACKGROUND: Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbations indicates a need to improve ICS actions. METHODS: Glucoc...

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Detalles Bibliográficos
Autores principales:	Mostafa, Mahmoud M., Rider, Christopher F., Shah, Suharsh, Traves, Suzanne L., Gordon, Paul M. K., Miller-Larsson, Anna, Leigh, Richard, Newton, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357449/ https://www.ncbi.nlm.nih.gov/pubmed/30704470 http://dx.doi.org/10.1186/s12920-018-0467-2

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