CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma

BACKGROUND: Osteosarcoma (OS) is a common malignant cancer in children and adolescents and has a cure rate that has not improved in the last two decades. CYT997 (lexibulin) is a novel potent microtubule-targeting agent with various anticancer activities, such as proliferation inhibition, vascular di...

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Detalles Bibliográficos
Autores principales: Wang, Zongyi, Yin, Fei, Xu, Jing, Zhang, Tao, Wang, Gangyang, Mao, Ming, Wang, Zhuoying, Sun, Wei, Han, Jing, Yang, Mengkai, Jiang, Yafei, Hua, Yingqi, Cai, Zhengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357486/
https://www.ncbi.nlm.nih.gov/pubmed/30704503
http://dx.doi.org/10.1186/s13046-019-1047-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357486/
https://www.ncbi.nlm.nih.gov/pubmed/30704503
http://dx.doi.org/10.1186/s13046-019-1047-9

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