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Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx–DDB1 Interaction
BACKGROUND & AIMS: Hepatitis B virus (HBV) infection is a major health concern worldwide. Although currently used nucleos(t)ide analogs efficiently inhibit viral replication, viral proteins transcribed from the episomal viral covalently closed circular DNA (cccDNA) minichromosome continue to be...
Autores principales: | Sekiba, Kazuma, Otsuka, Motoyuki, Ohno, Motoko, Yamagami, Mari, Kishikawa, Takahiro, Suzuki, Tatsunori, Ishibashi, Rei, Seimiya, Takahiro, Tanaka, Eri, Koike, Kazuhiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357790/ https://www.ncbi.nlm.nih.gov/pubmed/30704981 http://dx.doi.org/10.1016/j.jcmgh.2018.10.010 |
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