Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design

Two major pharmacological hurdles severely limit the widespread use of small peptides as therapeutics: poor proteolytic stability and membrane permeability. Importantly, low aqueous solubility also impedes the development of peptides for clinical use. Various elaborate side chain stapling chemistrie...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Tolbert, W. David, Hu, Hong-Gang, Gohain, Neelakshi, Zou, Yan, Niu, Fan, He, Wang-Xiao, Yuan, Weirong, Su, Jia-Can, Pazgier, Marzena, Lu, Wuyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357863/
https://www.ncbi.nlm.nih.gov/pubmed/30809370
http://dx.doi.org/10.1039/c8sc03275k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357863/
https://www.ncbi.nlm.nih.gov/pubmed/30809370
http://dx.doi.org/10.1039/c8sc03275k

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