Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice

β-Amyloid (Aβ) accumulation is an early event of Alzheimer’s disease (AD) pathogenesis. Inhibition of Aβ production by β-secretase (BACE) has been proposed as a potential therapeutic strategy for AD. However, BACE inhibitors lack specificity and have had limited clinical benefit. To better study the...

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Detalles Bibliográficos
Autores principales: Evans, Charles E., Thomas, Rhian S., Freeman, Thomas J., Hvoslef-Eide, Martha, Good, Mark A., Kidd, Emma J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357873/
https://www.ncbi.nlm.nih.gov/pubmed/30572184
http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357873/
https://www.ncbi.nlm.nih.gov/pubmed/30572184
http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.011

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