Controlling the dynamics of the Nek2 leucine zipper by engineering of “kinetic” disulphide bonds

Nek2 is a dimeric serine/ threonine protein kinase that belongs to the family of NIMA-related kinases (Neks). Its N-terminal catalytic domain and its C-terminal regulatory region are bridged by a leucine zipper, which plays an important role in the activation of Nek2’s catalytic activity. Unusual co...

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Detalles Bibliográficos
Autores principales: Gutmans, Daniel S., Whittaker, Sara B-M, Asiani, Karishma, Atkinson, R. Andrew, Oregioni, Alain, Pfuhl, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358272/
https://www.ncbi.nlm.nih.gov/pubmed/30707691
http://dx.doi.org/10.1371/journal.pone.0210352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358272/
https://www.ncbi.nlm.nih.gov/pubmed/30707691
http://dx.doi.org/10.1371/journal.pone.0210352

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