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Controlling the dynamics of the Nek2 leucine zipper by engineering of “kinetic” disulphide bonds
Nek2 is a dimeric serine/ threonine protein kinase that belongs to the family of NIMA-related kinases (Neks). Its N-terminal catalytic domain and its C-terminal regulatory region are bridged by a leucine zipper, which plays an important role in the activation of Nek2’s catalytic activity. Unusual co...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358272/ https://www.ncbi.nlm.nih.gov/pubmed/30707691 http://dx.doi.org/10.1371/journal.pone.0210352 |