An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia

NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL), and cells harboring this mutation can become the predominant clone in relapsing disease. We s...

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Detalles Bibliográficos
Autores principales: Swaroop, Alok, Oyer, Jon A., Will, Christine M., Huang, Xiaoxiao, Yu, Wenbo, Troche, Catalina, Bulic, Marinka, Durham, Benjamin H., Wen, Qiang Jeremy, Crispino, John D., MacKerell, Alexander D., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358490/
https://www.ncbi.nlm.nih.gov/pubmed/30171259
http://dx.doi.org/10.1038/s41388-018-0474-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358490/
https://www.ncbi.nlm.nih.gov/pubmed/30171259
http://dx.doi.org/10.1038/s41388-018-0474-y

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