Cargando…

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

OBJECTIVE: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain unclear. Given the established roles of the hyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tooke, Benjamin P., Yu, Hui, Adams, Jessica M., Jones, Graham L., Sutton-Kennedy, Talisha, Mundada, Lakshmi, Qi, Nathan R., Low, Malcolm J., Chhabra, Kavaljit H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358536/ https://www.ncbi.nlm.nih.gov/pubmed/30503832 http://dx.doi.org/10.1016/j.molmet.2018.11.004

Ejemplares similares

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
por: Yu, Hui, et al.
Publicado: (2020)

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice
por: Chhabra, Kavaljit H., et al.
Publicado: (2017)

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses
por: Winkler, Zsuzsanna, et al.
Publicado: (2019)

A Parabrachial-Hypothalamic Cholecystokinin Neurocircuit Controls Counterregulatory Responses to Hypoglycemia
por: Garfield, Alastair S., et al.
Publicado: (2014)

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
por: Diggs-Andrews, Kelly A., et al.
Publicado: (2010)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

Relationship Between Hypoglycemia Awareness Status on Clarke/Gold Methods and Counterregulatory Response to Hypoglycemia
por: Rubin, Nathan T, et al.
Publicado: (2022)

SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity
por: Thompson, Zoe, et al.
Publicado: (2020)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Hypoglycemia during moderate intensity exercise reduces counterregulatory responses to subsequent hypoglycemia
por: Cade, W. Todd, et al.
Publicado: (2016)

Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice
por: Shankar, Kripa, et al.
Publicado: (2023)

Effects of Intensive Therapy and Antecedent Hypoglycemia on Counterregulatory Responses to Hypoglycemia in Type 2 Diabetes
por: Davis, Stephen N., et al.
Publicado: (2009)

BAD Modulates Counterregulatory Responses to Hypoglycemia and Protective Glucoprivic Feeding
por: Osundiji, Mayowa A., et al.
Publicado: (2011)

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
por: Gaspari, Sevasti, et al.
Publicado: (2023)

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons
por: Hu, Jun, et al.
Publicado: (2014)

Hypothalamic EphA5 Facilitates Counterregulatory Responses: Possible Role for Bidirectional Signaling Leading to Bistability That Enhances Responsiveness to Hypoglycemia
por: Mobbs, Charles V., et al.
Publicado: (2013)

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes
por: Yu, Hui, et al.
Publicado: (2022)

Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent Hypoglycemia: Role of Metabolic Reprogramming in Counterregulatory Failure
por: Poplawski, Michal M., et al.
Publicado: (2011)

Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
por: Szepietowska, Barbara, et al.
Publicado: (2011)

Impaired hepatic counterregulatory response to insulin-induced hypoglycemia in hepatic denervated pigs
por: Nielsen, Michael Festersen, et al.
Publicado: (2015)

Dissociation Between Hormonal Counterregulatory Responses and Cerebral Glucose Metabolism During Hypoglycemia
por: Lee, John J., et al.
Publicado: (2017)

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity
por: Kim, Geun Hyang, et al.
Publicado: (2018)

Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli
por: Otlivanchik, Oleg, et al.
Publicado: (2015)

Effects of Antecedent GABA(A) Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans
por: Hedrington, Maka S., et al.
Publicado: (2010)

Lactate activates hypothalamic POMC neurons by intercellular signaling
por: Órdenes, P., et al.
Publicado: (2021)

Effects of a Selective Serotonin Reuptake Inhibitor, Fluoxetine, on Counterregulatory Responses to Hypoglycemia in Healthy Individuals
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

The Medial Amygdalar Nucleus: A Novel Glucose-Sensing Region That Modulates the Counterregulatory Response to Hypoglycemia
por: Zhou, Ligang, et al.
Publicado: (2010)

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes
por: Chan, Owen, et al.
Publicado: (2013)

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes
Publicado: (2009)

Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones
por: Page, Kathleen A., et al.
Publicado: (2009)

Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons
por: Hill, Jennifer W.
Publicado: (2010)

Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
por: Souza, Gabriela F. P., et al.
Publicado: (2016)

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
por: Zanesco, Ariane Maria, et al.
Publicado: (2022)

Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
por: Zhou, Shengnan, et al.
Publicado: (2022)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
por: Burke, Luke K., et al.
Publicado: (2016)

MON-709 Single-Cell RNA-Sequencing Deciphers POMC Neuron Destiny
por: Yu, Hui, et al.
Publicado: (2020)

Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion
por: Briski, Karen P., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_poh0bgk3rv09paf0oq658a7jbi