Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

OBJECTIVE: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of ani...

Descripción completa

Detalles Bibliográficos
Autores principales: Aghanoori, Mohamad-Reza, Smith, Darrell R., Shariati-Ievari, Shiva, Ajisebutu, Andrew, Nguyen, Annee, Desmond, Fiona, Jesus, Carlos H.A., Zhou, Xiajun, Calcutt, Nigel A., Aliani, Michel, Fernyhough, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358538/
https://www.ncbi.nlm.nih.gov/pubmed/30545741
http://dx.doi.org/10.1016/j.molmet.2018.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358538/
https://www.ncbi.nlm.nih.gov/pubmed/30545741
http://dx.doi.org/10.1016/j.molmet.2018.11.008

Ejemplares similares