Natural helix 9 mutants of PPARγ differently affect its transcriptional activity

OBJECTIVE: The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-function mutations in PPARG result in familial partial l...

Descripción completa

Detalles Bibliográficos
Autores principales: Broekema, Marjoleine F., Massink, Maarten P.G., Donato, Cinzia, de Ligt, Joep, Schaarschmidt, Joerg, Borgman, Anouska, Schooneman, Marieke G., Melchers, Diana, Gerding, Martin N., Houtman, René, Bonvin, Alexandre M.J.J., Majithia, Amit R., Monajemi, Houshang, van Haaften, Gijs W., Soeters, Maarten R., Kalkhoven, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358588/
https://www.ncbi.nlm.nih.gov/pubmed/30595551
http://dx.doi.org/10.1016/j.molmet.2018.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358588/
https://www.ncbi.nlm.nih.gov/pubmed/30595551
http://dx.doi.org/10.1016/j.molmet.2018.12.005

Ejemplares similares