MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localize...

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Detalles Bibliográficos
Autores principales: Yan, Yahui, Rato, Claudia, Rohland, Lukas, Preissler, Steffen, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358605/
https://www.ncbi.nlm.nih.gov/pubmed/30710085
http://dx.doi.org/10.1038/s41467-019-08450-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358605/
https://www.ncbi.nlm.nih.gov/pubmed/30710085
http://dx.doi.org/10.1038/s41467-019-08450-4

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