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MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localize...
Autores principales: | Yan, Yahui, Rato, Claudia, Rohland, Lukas, Preissler, Steffen, Ron, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358605/ https://www.ncbi.nlm.nih.gov/pubmed/30710085 http://dx.doi.org/10.1038/s41467-019-08450-4 |
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