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On-demand serum-free media formulations for human hematopoietic cell expansion using a high dimensional search algorithm
Substitution of serum and other clinically incompatible reagents is requisite for controlling product quality in a therapeutic cell manufacturing process. However, substitution with chemically defined compounds creates a complex, large-scale optimization problem due to the large number of possible f...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358607/ https://www.ncbi.nlm.nih.gov/pubmed/30729186 http://dx.doi.org/10.1038/s42003-019-0296-7 |