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On-demand serum-free media formulations for human hematopoietic cell expansion using a high dimensional search algorithm

Substitution of serum and other clinically incompatible reagents is requisite for controlling product quality in a therapeutic cell manufacturing process. However, substitution with chemically defined compounds creates a complex, large-scale optimization problem due to the large number of possible f...

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Detalles Bibliográficos
Autores principales: Kim, Michelle M., Audet, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358607/
https://www.ncbi.nlm.nih.gov/pubmed/30729186
http://dx.doi.org/10.1038/s42003-019-0296-7