Aptamers as quality control tool for production, storage and biosimilarity of the anti-CD20 biopharmaceutical rituximab

Detailed analysis of biopharmaceuticals is crucial for safety, efficacy and stability. Aptamers, which are folded, single-stranded oligonucleotides, can be used as surrogate antibodies to detect subtle conformational changes. We aimed to generate and assess DNA aptamers against the therapeutic anti-...

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Detalles Bibliográficos
Autores principales: Wildner, Sabrina, Huber, Sara, Regl, Christof, Huber, Christian G., Lohrig, Urs, Gadermaier, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358617/
https://www.ncbi.nlm.nih.gov/pubmed/30710098
http://dx.doi.org/10.1038/s41598-018-37624-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358617/
https://www.ncbi.nlm.nih.gov/pubmed/30710098
http://dx.doi.org/10.1038/s41598-018-37624-1

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