Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms

Antimetabolites are small molecules that inhibit enzymes by mimicking physiological substrates. We report the discovery and structural elucidation of the antimetabolite 7-deoxy-sedoheptulose (7dSh). This unusual sugar inhibits the growth of various prototrophic organisms, including species of cyanob...

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Detalles Bibliográficos
Autores principales: Brilisauer, Klaus, Rapp, Johanna, Rath, Pascal, Schöllhorn, Anna, Bleul, Lisa, Weiß, Elisabeth, Stahl, Mark, Grond, Stephanie, Forchhammer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358636/
https://www.ncbi.nlm.nih.gov/pubmed/30710081
http://dx.doi.org/10.1038/s41467-019-08476-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358636/
https://www.ncbi.nlm.nih.gov/pubmed/30710081
http://dx.doi.org/10.1038/s41467-019-08476-8

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