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Crystal structure of the WD40 domain dimer of LRRK2

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein with both a Ras of complex (ROC) domain and a kinase domain (KD) and, therefore, exhibits both GTPase and kinase activities. Human genetics studies have linked LRRK2 as a major genetic contributor to familial and sporadic Parkinson’...

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Detalles Bibliográficos
Autores principales: Zhang, Pengfei, Fan, Ying, Ru, Heng, Wang, Li, Magupalli, Venkat Giri, Taylor, Susan S., Alessi, Dario R., Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358694/
https://www.ncbi.nlm.nih.gov/pubmed/30635421
http://dx.doi.org/10.1073/pnas.1817889116