Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity

Although human liver tumor cells have reduced metabolic functions as compared to primary human hepatocytes (PHH) they are widely used for pre-screening tests of drug metabolism and toxicity. The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizin...

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Detalles Bibliográficos
Autores principales: Ruoß, Marc, Damm, Georg, Vosough, Massoud, Ehret, Lisa, Grom-Baumgarten, Carl, Petkov, Martin, Naddalin, Silvio, Ladurner, Ruth, Seehofer, Daniel, Nussler, Andreas, Sajadian, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358789/
https://www.ncbi.nlm.nih.gov/pubmed/30654452
http://dx.doi.org/10.3390/ijms20020347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358789/
https://www.ncbi.nlm.nih.gov/pubmed/30654452
http://dx.doi.org/10.3390/ijms20020347

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