Cargando…

PCSK9 is Expressed in Human Visceral Adipose Tissue and Regulated by Insulin and Cardiac Natriuretic Peptides

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to and degrades the low-density lipoprotein receptor (LDLR), contributing to hypercholesterolemia. Adipose tissue plays a role in lipoprotein metabolism, but there are almost no data about PCSK9 and LDLR regulation in human adipocytes. We s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bordicchia, Marica, Spannella, Francesco, Ferretti, Gianna, Bacchetti, Tiziana, Vignini, Arianna, Di Pentima, Chiara, Mazzanti, Laura, Sarzani, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358804/ https://www.ncbi.nlm.nih.gov/pubmed/30634533 http://dx.doi.org/10.3390/ijms20020245

Ejemplares similares

Cardiac Natriuretic Peptides, Hypertension and Cardiovascular Risk
por: Sarzani, Riccardo, et al.
Publicado: (2017)

Association Between Cardiac Natriuretic Peptides and Lipid Profile: a Systematic Review and Meta-Analysis
por: Spannella, Francesco, et al.
Publicado: (2019)

Role of Cardiac Natriuretic Peptides in Heart Structure and Function
por: Sarzani, Riccardo, et al.
Publicado: (2022)

Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Inversely Associated with N-Terminal Pro B-Type Natriuretic Peptide in Older Men and Women
por: Spannella, Francesco, et al.
Publicado: (2022)

Prevalence and Control of Dyslipidemia in Patients Referred for High Blood Pressure: The Disregarded “Double-Trouble” Lipid Profile in Overweight/Obese
por: Spannella, Francesco, et al.
Publicado: (2019)

Antagonizing the renin–angiotensin–aldosterone system in the era of COVID-19
por: Sarzani, Riccardo, et al.
Publicado: (2020)

Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence
por: Sarzani, Riccardo, et al.
Publicado: (2021)

Painful and recurring injection site reaction to alirocumab and evolocumab in a young woman with familial hypercholesterolemia and effective therapeutic alternative based on inclisiran: a case report
por: Allevi, Massimiliano, et al.
Publicado: (2023)

The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common Theme
por: Sarzani, Riccardo, et al.
Publicado: (2021)

Renin-Angiotensin-System Inhibitors Are Associated With Lower In-hospital Mortality in COVID-19 Patients Aged 80 and Older
por: Spannella, Francesco, et al.
Publicado: (2022)

Associations of atrial natriuretic peptide with measures of insulin and adipose depots
por: Couch, Catharine A., et al.
Publicado: (2023)

The Gluten-Free Diet: Safety and Nutritional Quality
por: Saturni, Letizia, et al.
Publicado: (2010)

Effect of sacubitril/valsartan on renal function: a systematic review and meta‐analysis of randomized controlled trials
por: Spannella, Francesco, et al.
Publicado: (2020)

Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer
por: Islam, Md Obaidul, et al.
Publicado: (2019)

Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach
por: Ferretti, Gianna, et al.
Publicado: (2012)

Cherry Antioxidants: From Farm to Table
por: Ferretti, Gianna, et al.
Publicado: (2010)

Antioxidant and Pro-Oxidant Properties of Carthamus Tinctorius, Hydroxy Safflor Yellow A, and Safflor Yellow A
por: Bacchetti, Tiziana, et al.
Publicado: (2020)

Single-pill fixed-dose drug combinations to reduce blood pressure: the right pill for the right patient
por: Sarzani, Riccardo, et al.
Publicado: (2022)

Radiological lung sequelae, functional status and symptoms in older patients 3 and 6 months after hospitalization for COVID-19 pneumonia
por: Di Pentima, Chiara, et al.
Publicado: (2023)

High density lipoproteins and oxidative stress in breast cancer
por: Mazzuferi, Gabriele, et al.
Publicado: (2021)

Heart hormones fueling a fire in fat
por: Collins, Sheila, et al.
Publicado: (2013)

Role of Cardio-Renal Dysfunction, Inflammation Markers, and Frailty on In-Hospital Mortality in Older COVID-19 Patients: A Cluster Analysis
por: Spannella, Francesco, et al.
Publicado: (2023)

Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes
por: Kovacova, Zuzana, et al.
Publicado: (2016)

Altered inflammation, paraoxonase-1 activity and HDL physicochemical properties in obese humans with and without Prader-Willi syndrome
por: Ferretti, Gianna, et al.
Publicado: (2012)

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway
por: Cianfruglia, Laura, et al.
Publicado: (2020)

Exploring the role of Paraoxonase-2 in bladder cancer: analyses performed on tissue samples, urines and cell culturess
por: Bacchetti, Tiziana, et al.
Publicado: (2017)

Visceral adiposity, insulin resistance and cancer risk
por: Donohoe, Claire L, et al.
Publicado: (2011)

Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance
por: Du, Xuan, et al.
Publicado: (2018)

Chronic Kidney Disease Is Characterized by “Double Trouble” Higher Pulse Pressure plus Night-Time Systolic Blood Pressure and More Severe Cardiac Damage
por: Fedecostante, Massimiliano, et al.
Publicado: (2014)

Effects of Seven Weeks of Combined Physical Training on High-Density Lipoprotein Functionality in Overweight/Obese Subjects
por: Bacchetti, Tiziana, et al.
Publicado: (2023)

SUBCUTANEOUS ADIPOSE TISSUE INSULIN RESISTANCE IS ASSOCIATED WITH VISCERAL ADIPOSITY IN POSTMENOPAUSAL WOMEN
por: Casey, Beret A., et al.
Publicado: (2014)

Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes PCSK9–Dependent Adipose Insulin Resistance
por: Shu, Xin, et al.
Publicado: (2022)

A 95-year-old patient with unexpected coronavirus disease 2019 masked by aspiration pneumonia: a case report
por: Spannella, Francesco, et al.
Publicado: (2020)

Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice
por: Giulietti, Federico, et al.
Publicado: (2020)

Glucose Uptake and Oxidative Stress in Caco-2 Cells: Health Benefits from Posidonia oceanica (L.) Delile
por: Morresi, Camilla, et al.
Publicado: (2022)

Negative association of acetate with visceral adipose tissue and insulin levels
por: Layden, Brian T, et al.
Publicado: (2012)

Visceral Adipose Tissue is Associated with Insulin Resistance in Hemodialyzed Patients
por: Giers, Kinga, et al.
Publicado: (2015)

Visceral Adipose Tissue Phospholipid Signature of Insulin Sensitivity and Obesity
por: Palau-Rodriguez, Magalí, et al.
Publicado: (2021)

Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance
por: Wu, Wei, et al.
Publicado: (2017)

Identification of a Novel Score for Adherence to the Mediterranean Diet That Is Inversely Associated with Visceral Adiposity and Cardiovascular Risk: The Chrono Med Diet Score (CMDS)
por: De Matteis, Carlo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sdac29s8k7vnhmduc2a8uon78k