Synthesis and Biochemical Evaluation of Lid-Open d-Amino Acid Oxidase Inhibitors

Most of the known inhibitors of d-amino acid oxidase (DAAO) are small polar molecules recognized by the active site of the enzyme. More recently a new class of DAAO inhibitors has been disclosed that interacts with loop 218−224 at the top of the binding pocket. These compounds have a significantly l...

Descripción completa

Detalles Bibliográficos
Autores principales: Szilágyi, Bence, Hargitai, Csilla, Kelemen, Ádám A., Rácz, Anita, Ferenczy, György G., Volk, Balázs, Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358909/
https://www.ncbi.nlm.nih.gov/pubmed/30646619
http://dx.doi.org/10.3390/molecules24020290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358909/
https://www.ncbi.nlm.nih.gov/pubmed/30646619
http://dx.doi.org/10.3390/molecules24020290

Ejemplares similares