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Synthesis and Biochemical Evaluation of Lid-Open d-Amino Acid Oxidase Inhibitors
Most of the known inhibitors of d-amino acid oxidase (DAAO) are small polar molecules recognized by the active site of the enzyme. More recently a new class of DAAO inhibitors has been disclosed that interacts with loop 218−224 at the top of the binding pocket. These compounds have a significantly l...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358909/ https://www.ncbi.nlm.nih.gov/pubmed/30646619 http://dx.doi.org/10.3390/molecules24020290 |