Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects

A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine receptor (nAChR)-selectivity analogues. The analogues were...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chen, Wu, Pengxiang, Zhu, He, Grieco, Paolo, Yu, Ruihe, Gao, Xinmei, Wu, Guiyue, Wang, Dong, Xu, Hanmei, Qi, Weiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358911/
https://www.ncbi.nlm.nih.gov/pubmed/30669328
http://dx.doi.org/10.3390/molecules24020337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358911/
https://www.ncbi.nlm.nih.gov/pubmed/30669328
http://dx.doi.org/10.3390/molecules24020337

Ejemplares similares