Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine their ability to modulate TCR activation. Of these com...

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Detalles Bibliográficos
Autores principales: Khlebnikov, Andrei I., Schepetkin, Igor A., Kishkentaeva, Anarkul S., Shaimerdenova, Zhanar R., Atazhanova, Gayane A., Adekenov, Sergazy M., Kirpotina, Liliya N., Quinn, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358946/
https://www.ncbi.nlm.nih.gov/pubmed/30669433
http://dx.doi.org/10.3390/molecules24020350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358946/
https://www.ncbi.nlm.nih.gov/pubmed/30669433
http://dx.doi.org/10.3390/molecules24020350

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