Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

The feasibility of upscaling the formulation of co-amorphous indomethacin-lysine from lab-scale to pilot-scale spray drying was investigated. A 2(2) full factorial design of experiments (DoE) was employed at lab scale. The atomization gas flow rate (F(atom), from 0.5 to 1.4 kg/h) and outlet temperat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kasten, Georgia, Duarte, Íris, Paisana, Maria, Löbmann, Korbinian, Rades, Thomas, Grohganz, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358949/
https://www.ncbi.nlm.nih.gov/pubmed/30634423
http://dx.doi.org/10.3390/pharmaceutics11010024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358949/
https://www.ncbi.nlm.nih.gov/pubmed/30634423
http://dx.doi.org/10.3390/pharmaceutics11010024

Ejemplares similares