Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy

Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the endogenous inhibitors, Tissue Inhibitor of Me...

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Detalles Bibliográficos
Autores principales: Jiang, Bingjie, Liu, Jian, Lee, Meng Huee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359047/
https://www.ncbi.nlm.nih.gov/pubmed/30641935
http://dx.doi.org/10.3390/molecules24020255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359047/
https://www.ncbi.nlm.nih.gov/pubmed/30641935
http://dx.doi.org/10.3390/molecules24020255

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