Cargando…

Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy

Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the endogenous inhibitors, Tissue Inhibitor of Me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Bingjie, Liu, Jian, Lee, Meng Huee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359047/ https://www.ncbi.nlm.nih.gov/pubmed/30641935 http://dx.doi.org/10.3390/molecules24020255

Ejemplares similares

Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition
por: Jiang, Bingjie, et al.
Publicado: (2017)

Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
por: Vincent, Zoë L, et al.
Publicado: (2015)

Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast
por: Kim, Hee Jung, et al.
Publicado: (2006)

MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma
por: Zhang, Wen-jing, et al.
Publicado: (2019)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
por: Dimic-Janjic, Sanja, et al.
Publicado: (2023)

Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
por: Mori, Sachiko, et al.
Publicado: (2012)

Expression of MMP-2, −7, −9, MT1-MMP and TIMP-1 and −2 has no prognostic relevance in patients with advanced epithelial ovarian cancer
por: BRUN, JEAN-LUC, et al.
Publicado: (2012)

Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
por: Lu, Xiaofei, et al.
Publicado: (2016)

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP
por: Shiryaev, S A, et al.
Publicado: (2013)

TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis
por: Valacca, Cristina, et al.
Publicado: (2015)

Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases
por: Jakubowska, Katarzyna, et al.
Publicado: (2016)

Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects
por: Duan, Jing Xian, et al.
Publicado: (2015)

MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors
por: Jinga, D C, et al.
Publicado: (2006)

Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
por: Forsblom, Erik, et al.
Publicado: (2021)

TIMP-1, TIMP-2 and MMP-9 as prognostic markers for clinical outcome in sepsis
por: Hoffmann, U, et al.
Publicado: (2003)

Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function
por: Strouhalova, Katerina, et al.
Publicado: (2023)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
por: Huang, Xiwen, et al.
Publicado: (2021)

Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
por: Kuźnik-Trocha, Kornelia, et al.
Publicado: (2020)

Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma
por: Salmela, M T, et al.
Publicado: (2001)

MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models
por: Fioruci-Fontanelli, Beatriz Aparecida, et al.
Publicado: (2015)

The Imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 Contributes to Collagen Deposition Disorder in Diabetic Non-Injured Skin
por: Zhou, Peng, et al.
Publicado: (2021)

Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol
por: Balli, Umut, et al.
Publicado: (2016)

Assessment of RANTES, MIP4A, MMP7, MMP9, MMP14, TIMP 1, TIMP 2 and TIMP 3 concentration in the follicular fluid of patients undergoing in vitro fertilization/embryo transfer procedure
por: Adamczak, Rafał, et al.
Publicado: (2023)

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis
por: Łanocha-Arendarczyk, Natalia, et al.
Publicado: (2018)

Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma
por: Anne, Talvensaari-Mattila, et al.
Publicado: (2010)

Mechanisims of asthma and allergic disease – 1077. Differential expression and roles oF MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in allergic rhinitis
por: Mori, Sachiko, et al.
Publicado: (2013)

MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane
por: Miyagawa, Takuya, et al.
Publicado: (2019)

An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
por: Demir, Nazlim Aktug, et al.
Publicado: (2023)

Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma
por: Wang, Ning, et al.
Publicado: (2012)

The Catalytic Domain Mediates Homomultimerization of MT1-MMP and the Prodomain Interferes with MT1-MMP Oligomeric Complex Assembly
por: Fogarasi, Marton, et al.
Publicado: (2022)

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
por: Pahwa, Sonia, et al.
Publicado: (2014)

The increased of MMP-9 and MMP-2 with the decreased of TIMP-1 on the uterosacral ligament after childbirth
por: Rahajeng, Rahajeng
Publicado: (2018)

TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model
por: Niño, Maria Eugenia, et al.
Publicado: (2017)

Expression of MMP-2 and TIMP-1 in Renal Tissue of Patients with Chronic Active Antibody-mediated Renal Graft Rejection
por: Yan, Qiang, et al.
Publicado: (2012)

Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
por: Azevedo Martins, Jordana Maria, et al.
Publicado: (2020)

Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
por: Lorente, L, et al.
Publicado: (2010)

Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
por: Lorente, L, et al.
Publicado: (2011)

Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer
por: Böckelman, Camilla, et al.
Publicado: (2018)

MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy
por: Zhang, Yuyi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ucatlous6augaprbehubs609m5