AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK

Overexpression of Pim kinases has an oncogenic/pro-survival role in many hematological and solid cancers. AZD1208 is a pan-Pim kinase inhibitor that has anti-cancer and anti-adipogenic actions. Here, we investigated the effects of AZD1208 on the growth of 93T449 cells, a differentiated human liposar...

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Detalles Bibliográficos
Autores principales: Yadav, Anil Kumar, Kumar, Vinoth, Bailey, David Bishop, Jang, Byeong-Churl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359068/
https://www.ncbi.nlm.nih.gov/pubmed/30654529
http://dx.doi.org/10.3390/ijms20020363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359068/
https://www.ncbi.nlm.nih.gov/pubmed/30654529
http://dx.doi.org/10.3390/ijms20020363

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