Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase LC-MS analysis of tetrabenazine aci...

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Detalles Bibliográficos
Autores principales: Ettouati, Laurent, Senta-Loys, Zoé, Bourgeois, Sandrine, Fenet, Bernard, Le Borgne, Marc, Fessi, Hatem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359103/
https://www.ncbi.nlm.nih.gov/pubmed/30669539
http://dx.doi.org/10.3390/pharmaceutics11010044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359103/
https://www.ncbi.nlm.nih.gov/pubmed/30669539
http://dx.doi.org/10.3390/pharmaceutics11010044

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