Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We investigated the trypanocidal activities and mode of action of selected 3-aminosteroids against Trypanosoma brucei brucei. The in vitro activity of se...

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Detalles Bibliográficos
Autores principales: Nnadi, Charles O., Ebiloma, Godwin U., Black, Jennifer A., Nwodo, Ngozi J., Lemgruber, Leandro, Schmidt, Thomas J., de Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359104/
https://www.ncbi.nlm.nih.gov/pubmed/30642032
http://dx.doi.org/10.3390/molecules24020268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359104/
https://www.ncbi.nlm.nih.gov/pubmed/30642032
http://dx.doi.org/10.3390/molecules24020268

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