Cargando…

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs

Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We investigated the trypanocidal activities and mode of action of selected 3-aminosteroids against Trypanosoma brucei brucei. The in vitro activity of se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nnadi, Charles O., Ebiloma, Godwin U., Black, Jennifer A., Nwodo, Ngozi J., Lemgruber, Leandro, Schmidt, Thomas J., de Koning, Harry P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359104/ https://www.ncbi.nlm.nih.gov/pubmed/30642032 http://dx.doi.org/10.3390/molecules24020268

Ejemplares similares

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis
por: Nnadi, Charles Okeke, et al.
Publicado: (2018)

Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes
por: Ebiloma, Godwin U., et al.
Publicado: (2018)

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora
por: Ungogo, Marzuq A., et al.
Publicado: (2020)

Antitrypanosomal Effects of Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler Extracts on African Trypanosomes
por: Dofuor, Aboagye Kwarteng, et al.
Publicado: (2019)

Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy
por: Rodenko, Boris, et al.
Publicado: (2015)

Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan Propolis
por: Siheri, Weam, et al.
Publicado: (2019)

Antitrypanosomal properties of Anogeissus leiocarpa extracts and their inhibitory effect on trypanosome alternative oxidase
por: Tauheed, Abdullah M., et al.
Publicado: (2022)

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes
por: Zoltner, Martin, et al.
Publicado: (2020)

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents
por: Nwodo, Ngozi Justina, et al.
Publicado: (2015)

Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage
por: Ibrahim, M. A., et al.
Publicado: (2010)

Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis
por: Dofuor, Aboagye Kwarteng, et al.
Publicado: (2021)

African trypanosomes
por: Cayla, Mathieu, et al.
Publicado: (2019)

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy
por: Zheng, Yang, et al.
Publicado: (2023)

Partially Purified Leaf Fractions of Azadirachta indica Inhibit Trypanosome Alternative Oxidase and Exert Antitrypanosomal Effects on Trypanosoma congolense
por: Tauheed, Abdullah M., et al.
Publicado: (2021)

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense
por: Nnadi, Charles Okeke, et al.
Publicado: (2017)

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA–protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast
por: Millan, Cinthia R., et al.
Publicado: (2017)

Imaging African trypanosomes
por: MacLean, L, et al.
Publicado: (2013)

Experimental Hemorrhagic Shock Protocol in Swine Models: The Effects of 21-Aminosteroid on the Small Intestine
por: Bouboulis, George, et al.
Publicado: (2018)

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds
por: Alkhaldi, Abdulsalam AM, et al.
Publicado: (2019)

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium
por: Zheoat, Ahmed M., et al.
Publicado: (2021)

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei
por: Kelly, John M., et al.
Publicado: (2012)

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies
por: Cisneros, David, et al.
Publicado: (2022)

Social Motility in African Trypanosomes
por: Oberholzer, Michael, et al.
Publicado: (2010)

Antigenic variation in African trypanosomes
por: Horn, David
Publicado: (2014)

Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion
por: Briggs, Emma, et al.
Publicado: (2018)

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers
por: Kenmogne, Lucie Carolle, et al.
Publicado: (2015)

Exploiting the Achilles’ heel of membrane trafficking in trypanosomes
por: Zoltner, Martin, et al.
Publicado: (2016)

Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor
por: Conti, Paola, et al.
Publicado: (2011)

The Killing of African Trypanosomes by Ethidium Bromide
por: Roy Chowdhury, Arnab, et al.
Publicado: (2010)

Cell–cell communication in African trypanosomes
por: McWilliam, K. R.
Publicado: (2023)

Histone deacetylases as targets for antitrypanosomal drugs
por: Zuma, Aline A, et al.
Publicado: (2018)

Antitrypanosomal butanolides from Aiouea trinervis
por: Nunes, Felipe Oliveira, et al.
Publicado: (2020)

Enantiospecific antitrypanosomal in vitro activity of eflornithine
por: Boberg, Mikael, et al.
Publicado: (2021)

Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei
por: Cerone, Michela, et al.
Publicado: (2019)

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F
por: Voermans, P. H., et al.
Publicado: (1996)

THE EXISTENCE OF A CYTOSTOME AND THE OCCURRENCE OF PINOCYTOSIS IN THE TRYPANOSOME, TRYPANOSOMA MEGA
por: Steinert, M., et al.
Publicado: (1960)

Immunobiology of African Trypanosomes: Need of Alternative Interventions
por: Baral, Toya Nath
Publicado: (2010)

Early Invasion of Brain Parenchyma by African Trypanosomes
por: Frevert, Ute, et al.
Publicado: (2012)

A Cell-surface Phylome for African Trypanosomes
por: Jackson, Andrew P., et al.
Publicado: (2013)

The within-host dynamics of African trypanosome infections
por: Matthews, Keith R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n5m22hlqpf09g1ba12v412p1s3