S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate

We recently reported that (E)-5′-vinylphosphonate (5′-VP) is a metabolically-stable phosphate mimic for siRNA and demonstrated that 5′-VP improves the potency of the fully modified siRNAs in vivo. Here, we report an alternative synthesis of 5′-VP modified guide strand using S-pivaloyl-2-thioethyl (t...

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Detalles Bibliográficos
Autores principales: Nikan, Mehran, Li, Wenyu, Kinberger, Garth A., Seth, Punit P., Swayze, Eric E., Prakash, Thazha P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359142/
https://www.ncbi.nlm.nih.gov/pubmed/30634486
http://dx.doi.org/10.3390/molecules24020225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359142/
https://www.ncbi.nlm.nih.gov/pubmed/30634486
http://dx.doi.org/10.3390/molecules24020225

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