Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure–Activity Relations of New Inhibitors of HDAC and/or Tubulin Function

New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages of varying length to oxazole-bridged combretastatin A-4 analogous caps. While their antiproliferative and microtubule disrupting effect was most...

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Detalles Bibliográficos
Autores principales: Schmitt, Florian, Gosch, Lisa Chiara, Dittmer, Alexandra, Rothemund, Matthias, Mueller, Thomas, Schobert, Rainer, Biersack, Bernhard, Volkamer, Andrea, Höpfner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359144/
https://www.ncbi.nlm.nih.gov/pubmed/30658435
http://dx.doi.org/10.3390/ijms20020383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359144/
https://www.ncbi.nlm.nih.gov/pubmed/30658435
http://dx.doi.org/10.3390/ijms20020383

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