Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire

YYB-101 is a humanized rabbit anti-human hepatocyte growth factor (HGF)-neutralizing antibody currently in clinical trial. To test the effect of HGF neutralization with antibody on anti-cancer T cell immunity, we generated surrogate antibodies that are reactive to the mouse homologue of the epitope...

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Detalles Bibliográficos
Autores principales: Kim, Soohyun, Lee, Hyunho, Noh, Jinsung, Lee, Yonghee, Han, Haejun, Yoo, Duck Kyun, Kim, Hyori, Kwon, Sunghoon, Chung, Junho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359367/
https://www.ncbi.nlm.nih.gov/pubmed/30669409
http://dx.doi.org/10.3390/ijms20020417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359367/
https://www.ncbi.nlm.nih.gov/pubmed/30669409
http://dx.doi.org/10.3390/ijms20020417

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