Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles

The compound 4-thioureidoiminomethylpyridinium perchlorate (perchlozone(©)) is a novel anti-tuberculosis drug that is active in multiple drug resistance cases, but the compound is hepatotoxic. To decrease the systemic load and to achieve targeting, we encapsulated the drug into poly(lactic acid)-bas...

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Detalles Bibliográficos
Autores principales: Churilov, Leonid, Korzhikov-Vlakh, Viktor, Sinitsyna, Ekaterina, Polyakov, Dmitry, Darashkevich, Oleg, Poida, Mikhail, Platonova, Galina, Vinogradova, Tatiana, Utekhin, Vladimir, Zabolotnykh, Natalia, Zinserling, Vsevolod, Yablonsky, Peter, Urtti, Arto, Tennikova, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359407/
https://www.ncbi.nlm.nih.gov/pubmed/30577686
http://dx.doi.org/10.3390/pharmaceutics11010002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359407/
https://www.ncbi.nlm.nih.gov/pubmed/30577686
http://dx.doi.org/10.3390/pharmaceutics11010002

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