Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibilit...

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Detalles Bibliográficos
Autores principales: Lobo, João, Gillis, Ad J. M., Jerónimo, Carmen, Henrique, Rui, Looijenga, Leendert H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359418/
https://www.ncbi.nlm.nih.gov/pubmed/30634670
http://dx.doi.org/10.3390/ijms20020258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359418/
https://www.ncbi.nlm.nih.gov/pubmed/30634670
http://dx.doi.org/10.3390/ijms20020258

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