Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how an isomerisation from iminosugar pyrrolidine toward...

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Detalles Bibliográficos
Autores principales: Baudoin-Dehoux, Cécile, Castellan, Tessa, Rodriguez, Frédéric, Rives, Arnaud, Stauffert, Fabien, Garcia, Virginie, Levade, Thierry, Compain, Philippe, Génisson, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359432/
https://www.ncbi.nlm.nih.gov/pubmed/30669468
http://dx.doi.org/10.3390/molecules24020354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359432/
https://www.ncbi.nlm.nih.gov/pubmed/30669468
http://dx.doi.org/10.3390/molecules24020354

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