Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists

‘Biased’ ligands of G protein-coupled receptors (GPCRs) represent a type of promising analgesic with reduced on-target side effects. PZM21, a potent μ-opioid-receptor (μOR)-biased agonist with a new chemical scaffold compared to classic opioids, has been identified as a therapeutic lead molecule for...

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Detalles Bibliográficos
Autores principales: Ma, Mengjun, Sun, Jialin, Li, Menghua, Yu, Zixing, Cheng, Jingchao, Zhong, Bohua, Shi, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359544/
https://www.ncbi.nlm.nih.gov/pubmed/30641969
http://dx.doi.org/10.3390/molecules24020259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359544/
https://www.ncbi.nlm.nih.gov/pubmed/30641969
http://dx.doi.org/10.3390/molecules24020259

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