Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the major component of Lewy bodies in PD patients...

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Detalles Bibliográficos
Autores principales: Yuan, Ning-Ning, Cai, Cui-Zan, Wu, Ming-Yue, Zhu, Qi, Su, HuanXing, Li, Min, Ren, JiaoYan, Tan, Jie-Qiong, Lu, Jia-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360163/
https://www.ncbi.nlm.nih.gov/pubmed/30745870
http://dx.doi.org/10.3389/fphar.2019.00016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360163/
https://www.ncbi.nlm.nih.gov/pubmed/30745870
http://dx.doi.org/10.3389/fphar.2019.00016

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