Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death

Mutated proto-oncogene BRAF is a bona fide therapeutic target for melanomas. Regrettably, melanoma acquires resistance to BRAF inhibitors, e.g., vemurafenib (PLX4032) casting doubt on this promising melanoma targeted therapy. In this study, we explored the bioactivity of triterpenoid saponin cumingi...

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Detalles Bibliográficos
Autores principales: Cvetanova, Biljana, Shen, Ya-Ching, Shyur, Lie-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360185/
https://www.ncbi.nlm.nih.gov/pubmed/30745871
http://dx.doi.org/10.3389/fphar.2019.00030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360185/
https://www.ncbi.nlm.nih.gov/pubmed/30745871
http://dx.doi.org/10.3389/fphar.2019.00030

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