Cargando…

Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis

Switching aerobic respiration to anaerobic glycolysis of cancer cells plays an important role in development and progression of acquired resistance. Since vitamin C enabled the inhibition of glycolysis of cancer cells, and erlotinib-resistant sub-line of HCC827 (ER6 cells) switched its metabolic fea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Mingtong, Pang, Nengzhi, Wan, Ting, Huang, Yuanling, Wei, Tianyi, Jiang, Xuye, Zhou, Yujia, Huang, Yufeng, Yang, Hainan, Zhang, Zhenfeng, Yang, Lili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360421/ https://www.ncbi.nlm.nih.gov/pubmed/30719175 http://dx.doi.org/10.7150/jca.28087

Ejemplares similares

Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer
por: Ye, Mingtong, et al.
Publicado: (2017)

CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome–Pyroptosis Pathway
por: Jiang, Xuye, et al.
Publicado: (2021)

Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
por: Wang, Sufan, et al.
Publicado: (2018)

Nicotinamide Adenine Dinucleotide Precursor Suppresses Hepatocellular Cancer Progression in Mice
por: Pang, Nengzhi, et al.
Publicado: (2023)

Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside
por: Li, Qiuyan, et al.
Publicado: (2023)

Mitochondria-Targeted Mesoporous Organic Silica Nanoplatforms for Overcoming Cisplatin Resistance by Disturbing Mitochondrial Redox Homeostasis
por: Lv, Bin, et al.
Publicado: (2022)

Two Distinct Faces of Vitamin C: AA vs. DHA
por: Ferrada, Luciano, et al.
Publicado: (2021)

Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003–2018
por: Pan, Jie, et al.
Publicado: (2023)

Overcoming EGFR Resistance in Metastatic Colorectal Cancer Using Vitamin C: A Review
por: Machmouchi, Ahmad, et al.
Publicado: (2023)

The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring’s Muscle Development and Energy Homeostasis
por: Ghnaimawi, Saeed, et al.
Publicado: (2022)

IGF2BP1, a New Target to Overcome Drug Resistance in Melanoma?
por: Xi, Yufeng, et al.
Publicado: (2022)

NAD Supplement Alleviates Intestinal Barrier Injury Induced by Ethanol Via Protecting Epithelial Mitochondrial Function
por: Li, Wenli, et al.
Publicado: (2022)

Consequences of Disturbing Manganese Homeostasis
por: Baj, Jacek, et al.
Publicado: (2023)

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice
por: Pauter, Anna M., et al.
Publicado: (2014)

Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism
por: Landowski, Michael, et al.
Publicado: (2023)

A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached
por: Luxwolda, Martine F., et al.
Publicado: (2011)

Associations between Adipokines and Metabolic Dysfunction-Associated Fatty Liver Disease Using Three Different Diagnostic Criteria
por: Pan, Jie, et al.
Publicado: (2023)

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis
por: Duan, Junchao, et al.
Publicado: (2014)

Comparative analyses of DHA-Phosphatidylcholine and recombination of DHA-Triglyceride with Egg-Phosphatidylcholine or Glycerylphosphorylcholine on DHA repletion in n-3 deficient mice
por: Wu, Fang, et al.
Publicado: (2017)

The Potential of Docosahexaenoic Acid (DHA) in SARS-CoV-2 Management: DHA Reduces ACE2 Levels in Endothelial Cells
por: Huang, Shiqi, et al.
Publicado: (2021)

Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer
por: Yang, Lu, et al.
Publicado: (2022)

Inhibitory Mechanisms of DHA/CQ on pH and Iron Homeostasis of Erythrocytic Stage Growth of Plasmodium falciparum
por: Tang, Tian, et al.
Publicado: (2019)

The Efficacy of MAG-DHA for Correcting AA/DHA Imbalance of Cystic Fibrosis Patients
por: Morin, Caroline, et al.
Publicado: (2018)

Efficient Enrichment of Retinal DHA with Dietary Lysophosphatidylcholine-DHA: Potential Application for Retinopathies
por: Sugasini, Dhavamani, et al.
Publicado: (2020)

Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma
por: Hong, Xuan, et al.
Publicado: (2023)

In Vivo Digestion of Egg Products Enriched with DHA: Effect of the Food Matrix on DHA Bioavailability
por: Pineda-Vadillo, Carlos, et al.
Publicado: (2020)

Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells
por: Hsu, Chia-Chi, et al.
Publicado: (2021)

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis
por: Jakobsen, Caroline Hild, et al.
Publicado: (2008)

Novel agents and strategies for overcoming EGFR TKIs resistance
por: Niu, Fei-Yu, et al.
Publicado: (2014)

Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments
por: Kwon, Yoojung, et al.
Publicado: (2019)

Disturbed neurotransmitter homeostasis in ether lipid deficiency
por: Dorninger, Fabian, et al.
Publicado: (2019)

Modulation of redox homeostasis: A strategy to overcome cancer drug resistance
por: Li, Yang, et al.
Publicado: (2023)

DHA supplementation and pregnancy complications
por: Jiang, Yi, et al.
Publicado: (2023)

Impact of DHA from Algal Oil on the Breast Milk DHA Levels of Lactating Women: A Randomized Controlled Trial in China
por: Yang, Yue, et al.
Publicado: (2022)

Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance
por: Wang, Yuetong, et al.
Publicado: (2016)

HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs
por: Watanabe, Sho, et al.
Publicado: (2021)

Concurrent use of anlotinib overcomes acquired resistance to EGFR‐TKI in patients with advanced EGFR‐mutant non‐small cell lung cancer
por: Zhang, Chen, et al.
Publicado: (2021)

Radiomics in Stroke Neuroimaging: Techniques, Applications, and Challenges
por: Chen, Qian, et al.
Publicado: (2021)

Emerging strategies to overcome resistance to third-generation EGFR inhibitors
por: Shi, Kunyu, et al.
Publicado: (2022)

DHA brain uptake and APOE4 status: a PET study with [1-(11)C]-DHA
por: Yassine, Hussein N., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1542ma3pdrtbdv2qh0kkis689o