A regression based phase I clinical trial for late-onset toxicities without clinician elicitation

An extension of the isotonic regression based phase I clinical trial design is presented that incorporates partial follow-up times into estimation of the raw toxicity probabilities. This phase I clinical trial design, called the TITE-IR design, drastically decreases average trial duration by allowin...

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Detalles Bibliográficos
Autores principales: Chapple, Andrew G., Wojcik, Janusz J., McDaniel, Lee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360989/
https://www.ncbi.nlm.nih.gov/pubmed/30766934
http://dx.doi.org/10.1016/j.conctc.2019.100327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360989/
https://www.ncbi.nlm.nih.gov/pubmed/30766934
http://dx.doi.org/10.1016/j.conctc.2019.100327

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