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A regression based phase I clinical trial for late-onset toxicities without clinician elicitation
An extension of the isotonic regression based phase I clinical trial design is presented that incorporates partial follow-up times into estimation of the raw toxicity probabilities. This phase I clinical trial design, called the TITE-IR design, drastically decreases average trial duration by allowin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360989/ https://www.ncbi.nlm.nih.gov/pubmed/30766934 http://dx.doi.org/10.1016/j.conctc.2019.100327 |