Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection

Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect the insulin-producing β-cells from inflammatory damage. Closing this clinical gap requires the establishment of new disease models of islet i...

Descripción completa

Detalles Bibliográficos
Autores principales: Delgadillo-Silva, Luis Fernando, Tsakmaki, Anastasia, Akhtar, Nadeem, Franklin, Zara J., Konantz, Judith, Bewick, Gavin A., Ninov, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361155/
https://www.ncbi.nlm.nih.gov/pubmed/30679186
http://dx.doi.org/10.1242/dmm.036004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361155/
https://www.ncbi.nlm.nih.gov/pubmed/30679186
http://dx.doi.org/10.1242/dmm.036004

Ejemplares similares