Phosphorylation status at Smad3 linker region modulates transforming growth factor‐β‐induced epithelial‐mesenchymal transition and cancer progression

Smad3, a major transcription factor in transforming growth factor‐β (TGF‐β) signaling, plays critical roles in both tumor‐suppressive and pro‐oncogenic functions. Upon TGF‐β stimulation, the C‐terminal tail of Smad3 undergoes phosphorylation that is essential for canonical TGF‐β signaling. The Smad3...

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Detalles Bibliográficos
Autores principales: Ooshima, Akira, Park, Jinah, Kim, Seong‐Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361575/
https://www.ncbi.nlm.nih.gov/pubmed/30589983
http://dx.doi.org/10.1111/cas.13922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361575/
https://www.ncbi.nlm.nih.gov/pubmed/30589983
http://dx.doi.org/10.1111/cas.13922

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