Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. However, it remains unclear how outer membrane openings form. Here, we combined different correlat...

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Detalles Bibliográficos
Autores principales: Ader, Nicholas R, Hoffmann, Patrick C, Ganeva, Iva, Borgeaud, Alicia C, Wang, Chunxin, Youle, Richard J, Kukulski, Wanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361589/
https://www.ncbi.nlm.nih.gov/pubmed/30714902
http://dx.doi.org/10.7554/eLife.40712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361589/
https://www.ncbi.nlm.nih.gov/pubmed/30714902
http://dx.doi.org/10.7554/eLife.40712

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