A first order phase transition mechanism underlies protein aggregation in mammalian cells

The formation of misfolded protein aggregates is a hallmark of neurodegenerative diseases. The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble. However, most experimental assays are blind to this lag phase. We develop a quantitative assay base...

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Detalles Bibliográficos
Autores principales: Narayanan, Arjun, Meriin, Anatoli, Andrews, J Owen, Spille, Jan-Hendrik, Sherman, Michael Y, Cisse, Ibrahim I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Physics of Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361590/
https://www.ncbi.nlm.nih.gov/pubmed/30716021
http://dx.doi.org/10.7554/eLife.39695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361590/
https://www.ncbi.nlm.nih.gov/pubmed/30716021
http://dx.doi.org/10.7554/eLife.39695

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