Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells

Inactivation of the TP53 tumor suppressor gene is essential during cancer development and progression. Mutations of TP53 are often missense and occur in various human cancers. In some fraction of wild‐type (wt) TP53 tumors, p53 is inactivated by upregulated murine double minute homolog 2 (MDM2) and...

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Detalles Bibliográficos
Autores principales: Imanishi, Mamiko, Yamamoto, Yoshiyuki, Wang, Xiaoxuan, Sugaya, Akinori, Hirose, Mitsuaki, Endo, Shinji, Natori, Yukikazu, Yamato, Kenji, Hyodo, Ichinosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361612/
https://www.ncbi.nlm.nih.gov/pubmed/30488540
http://dx.doi.org/10.1111/cas.13893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361612/
https://www.ncbi.nlm.nih.gov/pubmed/30488540
http://dx.doi.org/10.1111/cas.13893

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